Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

نویسندگان

  • Hidemasa Torii
  • Toshihide Kurihara
  • Yuko Seko
  • Kazuno Negishi
  • Kazuhiko Ohnuma
  • Takaaki Inaba
  • Motoko Kawashima
  • Xiaoyan Jiang
  • Shinichiro Kondo
  • Maki Miyauchi
  • Yukihiro Miwa
  • Yusaku Katada
  • Kiwako Mori
  • Keiichi Kato
  • Kinya Tsubota
  • Hiroshi Goto
  • Mayumi Oda
  • Megumi Hatori
  • Kazuo Tsubota
چکیده

Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360-400nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New Research Routes to Fight Myopia — Author's Reply

Article history: Received 16 January 2017 Accepted 16 January 2017 Available online 19 January 2017 hypothesis. We are currently doing a clinical trial Minami Aoyama Eye Clinic in Tokyo, Japan using a violet light-emitting desktop light and violet light-transmitting eyeglasses (Clinical trial number: UMIN000021897). Also, a randomized clinical trial is underway on violet light transmitting eyeg...

متن کامل

بررسی عوامل مرتبط با پیشرفت نزدیک‌بینی در مراجعه‌کنندگان نزدیک‌بین به مرکز چشم‌پزشکی بیمارستان ولیعصر(عج) بیرجند در سال 1391

Background and Aim: Myopia is one of the most prevalent complaints of patients referring to ophthalmologists. Regarding the progressive nature of this complication, it was decided to assess the patients referring to the eye clinic of Valieasr hospital in Birjand (in 2012). Materials and Methods: In this cross- sectional survey,with simple non-probable sampling, a total of 403 myopic patients...

متن کامل

Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats

The Canadian government greeted 2014 with the first tier of its new energy-efficiency standards for light bulbs, which will effectively ban incandescent light bulbs by next year. But efficient lighting can have its own drawbacks. For instance, although devoid of the mercury used in compact fluorescent lamps (CFLs), some white lightemitting diodes (LEDs) emit a wavelength of light associated wit...

متن کامل

Role of micronutrients and natural antioxidants in fighting against HIV; a quick mini-review

Oxidative stress has been implicated in the progression of HIV to AIDS, since HIV usually replicates in a highly oxidized condition and CD4+ T lymphocytes can be activated via a cascade of internal oxidative pathways, which enhances the formation of proteins and enzymes. Thus, antioxidants should potentially be useful for the treatment and prevention of HIV infection as a new alterna...

متن کامل

Effects of Various Risk Factors on Myopia Progression

Background: Myopia has different prevalence rate worldwide and there is controversial points about its environmental risk factors. The prevalence of myopia in medical interns atShirazMedicalSchool and its probable risk factors were studied. Method: In this retrospective cross-sectional study, three hundred interns (7th-year medical students) at Shiraz University of Medical Sciences were examine...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2017